Paget's disease treatment

Paget's disease of bone Bisphosphonates. Bisphosphonates are medicines that help regulate bone growth. They work by affecting the cells that... Painkillers. Over-the-counter painkillers such as paracetamol and ibuprofen can help relieve pain caused by Paget's... Supportive therapies. Some people. Drug therapy for Paget disease should include bisphosphonate treatment with serial monitoring of bone markers. Response to therapy is indicated by reduction of symptoms and decreases in levels of.. Treatment of Paget's disease does not cure the disease but can provide prolonged periods of remission. Bisphosphonates, which decrease bone resorption by inhibiting osteoclast resorption, are the.. If you have Paget's disease of the breast, you will likely need surgery. The type of surgery depends on the condition of the skin around your nipple and how advanced the underlying cancer is. Surgical options include: Removing the entire breast (mastectomy). A mastectomy is an operation to remove all of your breast tissue

Paget's disease of bone - Treatment - NH

  1. Medications Used to Treat Paget's Disease In addition to being available in oral form, bisphosphonates are also available via IV therapy. There are different types of intravenous medications used to treat Paget's disease
  2. In most cases, treatment for Paget's disease involves taking medications to help slow or stop the progress of the disease. For patients who have complications, surgery may be needed to realign deformed bones or to help fractures heal
  3. The medical treatment of the bone of Paget's disease involves either medicines called bisphosphonates or injectable calcitonin. Doctors more commonly use these drugs to treat certain patients with osteoporosis
Skeletal System Pathology - Radiography 312 with Barwick

Paget Disease Treatment & Management: Approach

Analgesic, rehabilitative, surgical, and other measures may also be of benefit. The treatment of Paget disease of bone will be reviewed here. The pathogenesis, clinical manifestations, and diagnosis of this disorder are discussed separately. (See Clinical manifestations and diagnosis of Paget disease of bone . We suggest that bisphosphonate treatment may be effective in preventing or slowing the progress of hearing loss and osteoarthritis in joints adjacent to Paget's disease and may reverse paraplegia associated with spinal Paget's disease. We suggest treatment with a bisphosphonate before surgery on pagetic bone Bisphosphonates, such as zoledronic acid, pamidronate, alendronate, and risedronate, are the mainstay of treatment. Patients who do not tolerate bisphosphonates can be treated with calcitonin bisphosphonates are used to slow the progression of Paget's disease. They help the body control the bone-building process to stimulate more normal bone growth. pain relievers (analgesics) and non-steroidal anti-inflammatory drugs (NSAIDs) - are used to provide temporary pain relief. calcium and vitamin D - are both important for bone health

Paget’s Disease of Bone - Symptoms, Cause, Diagnosis

Treatment. There's no way to fix the changes that have already happened, such as hearing loss or deformed bones, but you can get help with the issues caused by Paget's. Options include: Physical. In most countries, surgery is the common treatment for extramammary Paget's disease (EMPD). However, if surgery is not possible, or desired, some patients use other options including: topical treatments (such as Imiquimod, also known as Aldara), CO2 laser, photodynamic therapy, cavitational ultrasonic surgical aspiration or radiotherapy Paget's disease is often treated with a group of drugs called bisphosphonates. These act mainly on the cells that break down old bone to regulate the process of bone renewal. They often help to ease any bone pain caused by Paget's disease, although it may take a few weeks for symptoms to improve. Types of bisphosphonates include As the disease often affects people differently, treatments of Paget's disease can vary. Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms Paget's disease of the nipple is usually associated with breast cancer. It's treated by removing the cancerous part of the breast, or sometimes the entire breast using a procedure called a mastectomy. You can discuss any concerns you have with your oncologist (cancer specialist), who will be able to explain each phase of your treatment

Diagnosis and Treatment of Paget's Disease of Bone

Management and outcome of perianal Paget's disease: a 6-decade institutional experience Perianal Paget's disease is associated with nonspecific symptoms, frequently delaying diagnosis. Wide local excision is the treatment of choice if negative margins can be obtained. Abdominoperineal resection should be considered for invasive disease Paget's Disease Diagnosis Detecting Paget's disease early is highly critical in minimizing the damage caused by the disease. Among the common basis for diagnosis include blood tests, x-rays, and bone scans. Patients with Paget's have elevated alkaline levels and display abnormalities in the bones seen in x-rays. Paget's Disease Treatment

Paget's disease of the breast - Diagnosis and treatment

Infusion Therapy Treatment for Paget's Disease Infusion

Paget's Disease: Treating with Physical Therapy. A slow-progressing bone disease that typically afflicts older adults, Paget's disease involves excessive and abnormal remodeling of bone. Throughout our lives, bone continuously breaks down and re-forms new bone; cells called osteoclasts absorb this broken-down bone matter, and. Extramammary Paget's Disease or EMPD is a very rare condition, and physicians need to depend on research studies for updated information on treating their patients. Both surgical and nonsurgical.

Video: Paget's Disease of Bone - Symptoms and Treatment

Paget's Disease of Bone Treatment, Symptoms & Diagnosi

Bisphosphonates are recommended as a first-line drug treatment for patients with symptomatic Paget's disease. Singer FR, Bone HG 3rd, Hosking DJ, et al. Paget's disease of bone: an Endocrine Society clinical practice guideline The Paget's Disease, Randomized Trial of Intensive versus Symptomatic Management (PRISM) study compared the effects of a treat to target strategy aimed at normalizing total ALP compared with a strategy aimed at controlling symptoms 54 in 1324 patients with PDB. The average age of participants at entry to the study was about 74 years with an.

Paget's Disease Diagnosis Detecting Paget's disease early is highly critical in minimizing the damage caused by the disease. Among the common basis for diagnosis include blood tests, x-rays, and bone scans. Patients with Paget's have elevated alkaline levels and display abnormalities in the bones seen in x-rays. Paget's Disease Treatment Paget's Disease as stated is a chronic pathological condition of the bones in which there is a disorder of the normal process of bone remodeling. Paget's Disease affects the skeletal bones. Studies estimate that about 1% of population in the United States have Paget's Disease


Orthopaedic treatment in Paget's disease is indicated for: severe disabling arthritis, particulary hip, knee and shoulder, severe bowing deformity of femur or tibia, sacomatous degeneration, and pathological fracture. Pathologic fractures occur with an incidence of 10-30% and present very challenging problems to the. A mild increase in SAP, up to twice the usual level, may indicate Paget's disease or another condition, such as liver disease or a bone fracture that is in the process of healing. However, a SAP level greater than twice the usual level strongly suggests Paget's disease, especially if the person's serum calcium level, phosphorus level, and.

Paget's Disease of Bone Endocrine Societ

The juvenile form of Paget's disease is different from the adult form. It is autosomal recessive, with gene locus 8q24 and results from mutations or deletions in the TNFRSF11B gene. These lead to a deficiency of osteoprotegerin, a member of the TNF-receptor superfamily. Osteoprotegerin inhibits osteoclast differentiation and bone resorption Alternative treatments for Paget's disease are primarily home treatments that should be part of your regular treatment program. Make sure you are consuming at least 1,000 milligrams of calcium and 600 IU of vitamin D daily. Women over 50 and men over 70 should increase that to 1,200 mg of calcium; also, after age 70 men and women should consume. Paget's Disease: Commonly Missed and Poorly Understood. Providing an overview of the condition, the article, 'Adult Paget's Disease of Bone', was published in 'Clinical Medicine'. It provided an overview of Paget's disease, including diagnosis, treatment, complications, and monitoring Paget's Disease Of The Bone: Symptoms, Causes, Diagnosis and Treatment (1) - Paget's disease of the bone is a long-term bone disorder resulting in the enlargement and deformation of bones. Paget's disease is the second most common type of bone disorder in the world. | PowerPoint PPT presentation | free to vie Paget's disease. Paget's disease of the bone occurs when a fault develops in your body's normal bone rebuilding process. Over time, Paget's disease can cause weak and deformed bones leading to pain, possible nerve and joint damage and other complications. Treatment with medicines can slow the progression of the disease

Paget's disease of the vulva is an unusual kind of skin cancer that arises from glandular cells. This disease appears as a red, velvety area with white islands of tissue on the vulva. At times it may be pink, and occasionally there are moist, oozing ulcerations that bleed easily. Most people with the condition will experience itching and. Although Paget's disease and osteoporosis can occur in the same person, they are completely different disorders with different causes. Despite their marked differences, many treatments for Paget's disease are also used to treat osteoporosis. The following disorders may be associated with Paget's disease as secondary characteristics Paget's Disease Staging and Treatment. Treatment of Paget's Disease is similar to that of more common types of breast cancer, including local therapy and, sometimes, systemic therapy. Local therapy is aimed at preventing the cancer from coming back in the breast. Local therapy includes surgery (lumpectomy or mastectomy) and may include radiation Bisphosphonates are first-line treatment for Paget's disease, and the initiation of the new bisphosphonates allows remarkable progress in healing. 1,2. Paget diseases are treatable. The US FDA has approved several drugs for the treatment of Paget disease. 3,4. Oral bisphosphonates are generally well-tolerated and are regarded as the most. Paget's disease is a condition involving focal overactivity of bone cells (osteoblasts and osteoclasts), which can result in significant skeletal morbidity. It is unclear in which bone cells the causative lesion resides. It is managed effectively with potent bisphosphonates, but treatment is difficult if these drugs are contraindicated. We describe a 75-year-old woman with Paget's disease.

Paget's Disease of Bone: Diagnosis and Treatmen

  1. Paget's disease of breast accounts for 5% of the breast cancers worldwide which makes it plenty much of a chronic and fatal to death kind of ailment. It is a rare disease but has various serious troubles linked with it so immediate diagnosis and action is required but first learn about every aspect of it
  2. Overview. Paget's disease of the breast, also called Paget's disease of the nipple, is a rare type of breast cancer. Symptoms differ from those of other types of breast cancer
  3. Paget's disease treatment involves medications that slow down the quick decomposition of bone tissue. Medications can also help to ease pain. You may require treatment to prevent complications like osteoarthritis, even if there are no symptoms at all
  4. Paget's disease of the nipple is a rare form of breast cancer in which cancer cells collect in or around the nipple. The cancer usually affects the ducts of the nipple first (small milk-carrying tubes), then spreads to the nipple surface and the areola (the dark circle of skin around the nipple)
  5. Although pain is a common symptom in Paget's disease, its cause is often heterogeneous, and pagetic pain may be difficult to distinguish from the pain due to secondary osteoarthritis in adjacent joints. 1 Pain relief has been noted in response to treatment with calcitonin 18 and bisphosphonates. 13-15, 19, 20 In the present study, in addition.
  6. Extramammary Paget disease (EMPD) is characterized by a chronic eczema-like rash of the skin around the genital regions of males and females.Under the microscope, this condition looks very similar to a condition that occurs on the breast called mammary Paget disease. The primary difference between the two is the location of the rash
  7. Paget's disease of the breast is characterized by inflammatory, eczema-like changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple

Paget's Disease — Symptoms, Causes, & Treatments MSK

  1. ance in men in some but not all studies
  2. In general, patients with extramammary Paget disease have a good prognosis with a 5-year overall survival rate of 75-95%. However, quality of life can be significantly impacted after radical surgery. Although extramammary Paget disease is usually intraepithelial, it can progress to invasive disease with metastases
  3. After diagnosis of Paget's disease, we recommend measurement of serum total alkaline phosphatase or, when warranted, a more specific marker of bone formation or bone resorption to assess the response to treatment or evolution of the disease in untreated patients
  4. Extramammary Paget's Disease (EMPD), is a rare and slow-growing malignancy which occurs within the epithelium and accounts for 6.5% of all Paget's disease. The clinical presentation of this disease is similar to the characteristics of mammary Paget's disease (MPD). However, unlike MPD, which occurs in large lactiferous ducts and then extends into the epidermis, EMPD originates in.

Paget's disease is the second most common metabolic bone disease to osteoporosis Prevalence [edit | edit source] After Osteoporosis, Paget's disease is the most common skeletal disorder. Paget's disease affects approximately 2% to 5% of the population older than 40 and seen in 10% of the population over the age of 70 years old Extramammary Paget's disease treatment. Wide local excision, vulvectomy, or if available, margin-controlled surgical excision (Mohs micrographic surgery) is the standard treatment for extramammary Paget's disease . Paraffin sections are preferred over frozen sections. The margin is sometimes difficult to define particularly when lesions are.

Treatment for Paget's disease. The main treatment for Paget's disease is surgery. Having further treatment depends on whether the cancer is DCIS or an invasive breast cancer. Macmillan is also here to support you. If you would like to talk, you can: call the Macmillan Support Line on 0808 808 00 00 Paget's disease of bone affects the structure of parts of one or more bones. In most cases it causes no symptoms and does not need treatment. Symptoms develop in some cases and pain in the affected part of bone is the most common symptom. Affected bones are weaker than normal and may become deformed and may break (fracture) more easily than normal The global Paget's Disease Treatment market is valued at xx million USD in 2020 and is expected to reach xx million USD by the end of 2026, growing at a CAGR of xx% between 2020 and 2026. The Asia-Pacific will occupy for more market share in following years, especially in China, also fast growing India and Southeast Asia regions Paget's disease of the bone interferes with the process in which your body replaces old bone with new. It speeds up the process of rebuilding bones, leaving them softer than usual or enlarged and abnormally shaped. It affects the pelvis, low back, hips, thighs, skull and arms, causing bone and joint pain or enlarged bones Paget's disease is the most common disease of the bones. It is an abnormal bone growth in which the bone tissue breaks down too fast and body speeds up the rebuilding process. The new bone formed is often weak and brittle

Paget's Disease of Bone: Symptoms, Diagnosis, Treatmen

The best treatment option for Paget's Disease of the Scrotum is considered to be surgery. In majority of cases, a wide surgical excision and removal of the entire tumor is the preferred treatment option. This may be followed by radiation therapy and/or chemotherapy The general outlook for patients with Paget disease is good, especially if treatment is administered before major changes have occurred in the bones. Treatment does not cure Paget disease, but it. The most effective treatment of Paget's disease is a single 5 mg infusion of zoledronic acid that can normalize serum alkaline phosphatase for 6.5 years. More common indications for treatment include bone pain, prevention of complications such as skeletal deformity and preparation for orthopedic procedures. The latter indication is appropriate.

Paget disease of bone is a focal disorder of the skeleton that can affect one or more bones. Many patients are discovered accidentally because of elevated serum alkaline phosphatase activity or an. Paget's disease of the bone, also known as Osteitis Deformans (Paget 1877) is a chronic inflammatory condition that results in the proliferation and softening of the bone that may affect any or all parts in the skeleton (Mann, 1990). It is characterised by increased bone remodelling, bone hypertrophy and abnormal bone structure

Paget's disease of bone is a disease that can result in enlarged and misshapen bones. In people with Paget's disease, there is excessive breakdown of bone tissue, and formation of new bone tissue causing the affected bone to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints near the affected bones Pagets Disease Treatment is a medical procedure / surgery that requires coordination between specialist surgeons, anesthetists and various other specialist medical professionals. This type of Orthopedics procedure / treatment can be considered reasonably expensive, especially given the skill set, experience, training and equipment used by the. Paget's Disease of the Penis is a rare type of Paget's disease that affects extramammary sites, or parts of the body outside of the breast. The condition causes lesions on the penis shaft. In addition to the penis, Extramammary Paget's Disease (EMPD) can also arise in the groin (vulva or scrotum) and perineum region Paget's Disease Treatment, Causes, & Symptoms. Symptoms of Paget's disease present as legions around the glands of the nipples, anus or genitals. The condition is more common among postmenopausal women, however, men can also develop the condition. Sufferers may experience itching, burning sensations, or pain in the affected area. Paget's. Paget disease of bone is a focal disorder of the skeleton that can affect one or more bones. Many patients are discovered accidentally because of elevated serum alkaline phosphatase activity or an abnormal skeletal radiograph intended to evaluate an unrelated condition. Patients are often asymptomatic, but a subset experience considerable.

Extramammary Paget's Disease Treatments — myEMPD

For most people, medical treatment of Paget's disease can effectively control symptoms, and patients can remain pain free. A small portion of patients can develop more severe symptoms as stated above, including deafness, congestive heart failure , fractures, arthritis , and development of bone tumors (sarcomas) Paget disease of the bone is a common, chronic bone disorder characterized by excessive abnormal bone remodeling.The classically described radiological appearances are expanded bone with a coarsened trabecular pattern. The pelvis, spine, skull, and proximal long bones are most frequently affected

Paget disease of the knee | Image | Radiopaedia

Paget's disease of bone Causes, symptoms, treatment

In the case of patients with anogenital Paget's disease, radiotherapy is the definitive method of treatment, especially to prevent recurrence. Dosages ranging from 40 to 50 Gy or even lower have. Paget's disease, or osteitis deformans, is a chronic metabolic disorder characterized by increased bone turnover and breakdown secondary to excessive and disorganized osteoclastic and osteoblastic activity (Fig. 48.1 ). The precise etiology is still unclear. The excessive breakdown of bone is followed by the formation of weak and abnormal bone Treatment is mainly supportive and involves the use of bisphosphonates to inhibit osteoclastic function. Paget disease of the bone should not be confused with Paget disease of the nipple or Paget disease of the vulva, which are named after the same physician. Epidemiolog Paget's disease is a medical condition characterized by faulty bone formation and bone deformities. The new bones formed are usually weak and brittle. After osteoporosis, it is the second most common bone metabolism disorder. When these bones fracture, they take much longer to heal. This is due to defects in the bone renewal process Bisphosphonates are considered to be the treatment of choice for people with Paget's disease of bone. However, the effects of bisphosphonates on patient-centred outcomes have not been extensively studied. There are insufficient data to determine whether reducing and maintaining biochemical markers of bone turnover to within the normal range.

Treatment. Most people with Paget's disease do not need treatment as treatment is generally reserved for people with symptoms. In some cases, a doctor may recommend treatment even if you don't have symptoms if imaging tests (such as a bone scan) and blood tests detect enough disease, especially if it is in areas of bone where complications may. Paget's disease of bone is a chronic bone disorder. Normally, there is a process in which your bones break down and then regrow. In Paget's disease, this process is abnormal. There is excessive breakdown and regrowth of bone. Because the bones regrow too quickly, they are bigger and softer than normal Symptoms, Risk Factors & Complications. Most people who have Paget's disease of bone have no symptoms. When symptoms occur, the most common complaint is bone pain. Read More About Symptoms & Risk Factors 15 months after the treatment. Discussion Paget's disease of the vulva is classified into primary and secondary Paget's disease; the former is of cutaneous origin, whereas the latter originates from other malignancies, such as those from the urogenital or gastrointestinal tracts(3-5). Primary Paget's disease is subdivided into three categories

With Paget's disease, more bone is absorbed than normal. The body tries to compensate, but makes too much bone that is abnormally large, deformed and very weak. The whole skeleton is affected by Paget's disease and can cause bone and joint pain throughout the body. Weak vertebrae can cause the spine to curve, and weight-bearing bones, such. Herbal Remedies for Paget's Disease by Planet Ayurveda are. 1. Yograj Guggul. Yograj Guggul is a classical herbal medicine used for pacifying Vata Dosha. The aggravation of Vata dosha is the cause of Paget's disorder. It is an ayurvedic formulation prepared by using 28 herbs with guggulu being the main ingredient. It has analgesic properties Paget's disease, described by Sir James Paget in 1874 [], is classified as mammary and extramammary subgroups.Extramammary Paget's disease (EMPD) is a rare condition that is part of a spectrum of intraepithelial adenocarcinomas characterized by proliferation of apocrine cells called Paget cells, located in the basal layer of the skin and often can reach to the entire epithelium thickness [] Paget's disease of bone is a common disease characterised by focal areas of increased bone turnover, affecting one or several bones throughout the skeleton. Paget's disease is often asymptomatic but can be associated with bone pain and other complications such as osteoarthritis, pathological fracture, bone deformity, deafness, and nerve compression syndromes Coming to MD Anderson for Paget disease treatment. Right away, Karrie decided to seek treatment at MD Anderson. It was 90 minutes away from her home outside of Beaumont, Texas, and she knew of the cancer center's prestigious reputation. She, her husband, mother and sister traveled for two days of appointments on May 8 and 9 -- just a few.

Supportive treatment of Paget disease of bone includes analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs) for pain. Orthotics help correct abnormal gait caused by bowed lower extremities. Some patients require orthopedic surgery (eg, hip or knee replacement, decompression of the spinal cord) The earliest description of spontaneous ASVT was by Cruveilhier in 1816, and the first elaborate account was provided by James Paget in 1875. 1, 2 In 1894, von Schroetter was the first to identify vascular trauma from muscle strain as a potential etiologic factor. 3 In 1948, Hughes coined the term Paget-Schroetter Syndrome (PSS) and published. Extramammary Paget's disease (EMPD) is a rare epidermal carcinoma that most often appears in the anogenital region [1]. It resembles Paget's disease of the nipple in appearing as isolated Paget cells or small groups of Paget cells rather than as a continuous mass [2, 3]. Typical Paget cell morphology includes a large nucleus and pale cytoplasm Paget's disease is what decays and effects the bones in a massive amount and effects 1.5 to 8.0% of the world population so must stay aware and informed of this rare yet harmful disease. (People Also Like To Read: What is Vaginal Dryness: Its Symptoms, Causes, and Treatments Perianal Paget disease treated with wide excision and thigh skin flap reconstruction: a case report and review of literature. Shen K, Luo H, Hu J, Xie Z Medicine (Baltimore) 2018 Jul;97(30):e11638. doi: 10.1097/MD.0000000000011638

Paget's disease of bone - Wikipedi

Paget's disease of the nipple is a type of cancer that has flaky nipples as a symptom. Upon examination, half of all people diagnosed with Paget's disease of the nipple have a palpable tumor beneath the nipple. In all, 95% of people with the condition have a tumor in the breast tissue, usually located near the milk ducts Paget disease is a rare form of breast cancer, making up 1-4% of all breast cancer cases, according to the National Cancer Institute.The disease first appears on the nipple and often extends to the areola. In many patients, Paget disease may also be associated with a tumor or tumors in the affected breast

Paget disease is commonly treated when: Certain bones, such as weight-bearing bones, are involved and the risk of fracture is higher. Bony changes are getting worse quickly (treatment can reduce the risk of fractures) Paget's disease can be confirmed with a blood test since a person with Paget's disease usually has high levels of serum alkaline phosphatase in blood. Moreover, a complete blood count (CBC) indicating anemia points to Paget's disease. Bone Biopsy. A small bone marrow sample is collected after local anesthesia, to be tested in a medical lab Extramammary Paget's disease (EMPD) is a rare neoplastic condition of apocrine gland-bearing skin, which may be associated with internal malignancy. Although surgical excision is the generally accepted standard of care for EMPD, treatment with topical imiquimod 5 percent cream has reportedly been efficacious in clearing lesions

Paget's Disease of Bone: A Useful Guide. Paget's disease of bone is a common medical condition that mainly affects people over the age of 50 in the UK. The condition is named after Sir James Paget, who identified it in the late 19th century. According to the Paget's Association website, the disease occurs in around 1% of UK adults over 55 Paget's disease typically occurs in persons after age 50, being most often diagnosed in those in their 60s. For every two males affected, one female is affected. Overview-Complications. Fractures. Head enlargement. Blindness and hearing loss with tinnitus and vertigo; deafness. Osteoarthritis Paget disease (osteitis deformans) is a chronic skeletal disorder characterized by abnormal and excessive remodeling of bone. The disease was named after Sir James Paget who described the condition in 1877 [] in a detailed essay recognized in the medical literature as a lesson in accurate and lucid writing [].Paget disease is estimated to affect approximately 3-4% of individuals older. Paget 's disease of the breast (PDB) is a rare disorder of the nipple-areola complex that may present clinically as a unilateral, eczematous, or ulcerated papule or plaque. This case highlights the importance of either punch or incisional wedge biopsy to establish a diagnosis of PDB for patients who present with chronic cutaneous changes of the nipple, areola, or skin of the breast. Paget disease of the breast is a rare type of breast cancer. It develops as a rash or other skin changes on the nipple, usually on only one breast. Paget disease of the breast is more common in women over the age of 50. Most women with Paget disease also have invasive ductal carcinoma or ductal carcinoma in situ (DCIS)

Learning Radiology - Osteosarcoma in Paget DiseasePathology Outlines - Fibrosarcoma of boneInvasive papillary breast cancer with Paget’s diseaseSt
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